甲状腺结节中偶然的Ga-DOTATATE吸收:指南导向的管理仍然合适吗?
Kyla Wright1, Jason C Fisher2, Gary D Rothberger3
1NYU Grossman School of Medicine, NYU Langone Health, New York, NY.
Surgery
|April 2, 2024
概括
甲状腺结核中偶发的-68DOTATATE吸收表明恶性瘤的发生率与一般人群相似. 目前关于管理甲状腺结节的指导方针适用于-68DOTATATE激活结节.
科学领域:
- 核医学是一种核医学.
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 氧葡萄糖 (FDG) PET是甲状腺结节恶性瘤的危险因素.
- -68DOTATATE (GaTATE) PET越来越多地用于神经内分泌瘤检测.
- 在甲状腺结节中偶然的GaTATE吸收需要评估当前的管理指南.
研究的目的:
- 为了评估甲状腺结节的恶性瘤风险,随着偶然的-68DOTATATE吸收.
- 为了确定当前的指导方针导向管理是否适合这些结节.
主要方法:
- 对1176个GaTATE PET扫描 (2012-2022) 的回顾性审查.
- 包括患有偶发的焦点甲状腺 GaTATE 吸收的患者.
- 使用贝塞斯达系统分析的活检;贝塞斯达III/IV结节经过分子测试 (ThyroSeq v3).
主要成果:
- 44名患者偶尔吸收了甲状腺甲酸;9名患者患有已知的甲状腺髓癌.
- 恶性瘤发生率为6.7% (2/30) 随着超声波和随访,和9.5% (2/21) 随着细胞病理学/组织病理学.
- 良性和恶性结节之间最大标准化摄取值没有显著差异.
结论:
- 甲状腺结核中的恶性发病率与一般人群的发病率相当.
- 针对甲状腺结节的指导管理是适当的,即使偶尔吸收了GaTATE.
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