在慢性血栓栓塞性肺病中,睡眠呼吸障碍和夜间低氧症
Hui-Ting Li1, Ping Yuan1, Rong Jiang1
1Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Internal medicine journal
|April 2, 2024
概括
在慢性血栓栓塞性肺病和肺高血压中,夜间低氧症更为严重. 虽然睡眠呼吸障碍的患病率相似,但低氧症的严重程度与这些患者的血液动力学有关.
科学领域:
- 肺部医学 肺部医学
- 睡眠医学 睡眠医学
- 心血管研究研究心血管研究
背景情况:
- 在慢性血栓栓塞性肺高血压 (CTEPH) 中观察到睡眠呼吸障碍 (SDB) 和夜间低氧症.
- 在SDB和CTEPH和慢性血栓塞性肺病没有肺高血压 (CTEPD没有PH) 之间的SDB和夜间低氧症的区别尚不清楚.
研究的目的:
- 调查CTEPH患者和没有PH的CTEPD患者中SDB和夜间低氧症的患病率和预测因素.
- 为了确定夜间低氧症严重程度和血液动力学参数之间的关系,在CTEPD与或没有PH.
主要方法:
- 一项比较研究招募了80名CTEPH患者和40名没有PH的CTEPD患者,他们接受了睡眠研究.
- 夜间低氧症被定义为平均SPO2<90%,严重程度被评估为T90% (SPO2<90%的时间百分比).
- 使用后勤和线性回归分析来比较SDB和组间的低氧化,并确定预测因素.
主要成果:
- 标志着阻塞性睡眠呼吸暂停 (OSA) 的SDB患病率在两组中都相似 (P=0.104).
- 在CTEPH (22/80) 患者中,夜间低氧症的发生率明显高于在没有PH (3/40) 的CTEPD患者中 (P=0.021).
- T90%与平均肺动脉压 (mPAP) 和肺血管阻力正相关,与心脏输出负相关. T90%,单呼吸一氧化碳扩散能力,性别和mPAP与夜间低氧症相关.
结论:
- 夜间低氧症在患有肺高血压的CTEPD患者中更为严重.
- 低氧症的严重程度 (T90%),而不是SDB,独立地与CTEPD的血液动力状况相关,有或没有PH.
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