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与病态近视发病和进展相关的因素:系统性审查和元分析
Fabian Yii1,2, Linda Nguyen3, Niall Strang4
1Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
概括
病态近视 (PM) 的发病和进展与轴长,年龄和球体等效折射有关. 需要更多的研究来确定PM的可修改风险因素.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 病态近视 (PM) 是一种严重的近视形式,具有显著的视力损伤.
- 了解影响PM发病和进展的因素对于早期干预和管理至关重要.
- 病理近视的META分析 (META-PM) 分类为PM的分类提供了一个框架.
研究的目的:
- 综合有关与病理近视 (PM) 发病和进展相关的因素的证据.
- 使用META-PM分类框架进行全面分析.
- 评估已识别的风险和预后因素的证据质量.
主要方法:
- 六项纵向研究 (5-18年) 的叙事综合和元分析.
- 包括调整了基线近视,年龄和性别的研究.
- 使用推,评估,开发和评估等级 (GRADE) 框架评估证据质量.
主要成果:
- 增加PM发病的几率与较大的轴长 (汇总OR:2.03),年龄较大 (汇总OR:1.07) 和更负的球体等效折射 (SER) (OR:0.77) 相关.
- 底部嵌显示出与PM发病有很强的关联 (OR:3.02),但证据较弱.
- 颗粒物进展与较大的轴长度 (聚合OR:1.23),较为负的SER (聚合OR:0.87),以及高等教育 (聚合OR:3.17) 有关.
- 种族和性别作为独立因素的证据是不确定的.
结论:
- 大多数已确定的PM风险和预后因素缺乏足够的支持证据,表明PM研究不足.
- 有可接受证据的当前因素在成年人中是不可修改的,缺乏个性化的见解.
- 进一步的纵向研究对于发现可修改的因素和PM的成像生物标志物至关重要.
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