有希望的益生菌发酵大豆奶可缓解急性腹:对微生物组和代谢组的洞察
Philippe Madjirebaye1,2, Zhen Peng1,2, Abdul Mueed1,2
1State Key Laboratory of Food Science and Resources, No. 235 Nanjing East Road, Nanchang, Jiangxi, 330047, PR China. xiongtao0907@163.com.
Food & function
|April 2, 2024
概括
发酵大豆奶 (FSM4) 通过调节肠道微生物群并减少炎症,有效缓解腹. FSM4促进有益细菌并产生抗炎代谢物,为胃肠道疾病提供治疗性饮食选择.
科学领域:
- 微生物学和肠道健康
- 营养科学 营养科学
- 胃肠病学 胃肠病学
背景情况:
- 发酵大豆奶 (FSM4) 具有显著的营养和健康益处.
- 了解FSM4缓解腹的机制对于其治疗应用至关重要.
- 在腹期间肠道微生物群和代谢物生产之间的相互作用尚未得到充分理解.
研究的目的:
- 在大鼠模型中研究FSM4的减轻腹效应和潜在机制.
- 分析FSM4在腹期间对肠道微生物群组成和血清代谢物概况的影响.
主要方法:
- 使用生物化学分析,肠道微生物群分析和腹大鼠模型中的血清代谢学.
- 将FSM4与非发酵大豆牛奶 (NFSM) 和对照组的效果进行比较.
- 评估了肠道微生物群多样性,丰富性和组成的变化,以及关键的炎症标志物和代谢物.
主要成果:
- 与NFSM相比,FSM4消费显著改善了腹症状并减少了全身炎症.
- FSM4增强了肠道微生物群的多样性,促进了有益的细菌 (如乳酸菌),同时抑制了有害物种.
- FSM4治疗导致与IL-10和有益微生物相关的抗炎代谢物 (L-ornithine,酸,乌尔索霍尔酸,18-oxooleate,cyclopentanethiol) 的水平增加.
结论:
- FSM4通过调节肠道微生物群和代谢物生产来缓解腹具有显著的治疗潜力.
- 特定的代谢物包括氨基酸,胆汁酸,18-oxooleate和cyclopentanethiol可能作为腹缓解的生物标志物.
- FSM4代表了一种有前途的抗炎饮食干预措施,用于控制腹和相关的胃肠道疾病.
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