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差分化甲状腺癌:临床,病理,突变和结果分析

Amit Agarwal¹, Nelson George¹, Niraj Kumari²

¹Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Indian journal of pathology & microbiology

|April 2, 2024

概括

差分化甲状腺癌 (PDTC) 往往表现为具有攻击性特征. 早期手术干预和确定预后因素对于改善这些具有挑战性的病例的生存至关重要.

科学领域:

在瘤学瘤学.
病理学病理学病理学
手术瘤学手术瘤学

背景情况:

差分化甲状腺癌 (PDTC) 带来了诊断和手术方面的挑战.
甲状腺癌 PDTC 是非触囊性甲状腺癌中死亡的一个重要原因.
了解PDTC特征对于临床管理至关重要.

研究的目的:

审查PDTC的组织学和分子特征.
确定影响PDTC生存的预后因素.
评估手术切除对PDTC结果的影响.

主要方法:

在30年的时间里,对39起PDTC案件进行了回顾性审查.
瘤特征的组织病理学分析,包括线粒分裂,亡和侵袭.
对BRAF,RET/PTC,RAS,PI3KCA和P53免疫组织化学的突变分析.

主要成果:

PDTC病例显示瘤大小 (中位数为9厘米) 和频繁的甲状腺外延伸 (67.7%).
常见的是诸如死 (65.7%) 和线粒分裂 (73.3%) 等侵袭性特征.
RAS突变最常见 (23.1%),瘤大小和线粒分裂是生存的独立风险因素.

结论:

PDTC通常具有需要积极管理的高级功能.
激进甲状腺切除术可以改善局部区域控制和生存率.
需要对预后因素进行进一步的研究,以预测PDTC过程.

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