在机械通风过程中中断加热加湿对雾化药物输送效率,温度和绝对湿度的影响:一个多实验室的试验室内研究
Sophie Jacquier1,2, Hui-Ling Lin3,4, Jie Li5,6
1CHRU Tours, Médecine Intensive Réanimation, INSERM CIC 1415, CRICS-TriggerSep F-CRIN Research Network, Tours, France.
Journal of aerosol medicine and pulmonary drug delivery
|April 2, 2024
概括
在机械通风 (MV) 期间关闭加热加湿并不能改善气溶的药物输送,但可以显著降低吸入气体的湿度,低于推水平.
科学领域:
- 关键护理医学 关键护理医学
- 呼吸系统疗法 呼吸系统疗法
- 制药科学 制药科学
背景情况:
- 机械通风 (MV) 需要启发气体加湿.
- 加热加湿可能会降低气溶药物递送效率.
- 在MV期间进行雾化的实践是有争议的.
研究的目的:
- 评估禁用加热加湿对吸入气溶剂量和成年MV中雾化期间气体湿度的影响.
- 将气溶输送与不同类型和放置的雾化器进行比较.
主要方法:
- 使用振动网和喷气式雾化器进行雾化阿尔布托罗尔,甲基和阿米卡辛硫酸.
- 在加湿器入口和Y片处放置了雾化器.
- 测量了气溶颗粒大小,绝对湿度 (AH) 和温度.
- 测试的气溶收集在内管外和冲击器阶段.
主要成果:
- 吸入剂量在加湿器入口处的雾化器比Y片更大.
- 禁用加湿没有改善,有时甚至降低了吸入的气溶剂量.
- 当加湿关闭时,吸入气体的湿度下降到建议水平以下 (<30 mgH2O/L).
- 在干燥电路中的雾化产生AH在10-20 mgH2O/L之间.
结论:
- 在雾化之前在MV期间中断加热加湿不会增强气溶的输送.
- 禁用加湿导致激发气体湿度水平极低.
- 在机械通风患者的雾化疗法期间,保持足够的加湿是至关重要的.
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