现实世界的成本效益分析:中国新诊断的质母细胞瘤的瘤治疗场
Yuliang Xiang1,2, Yingyao Chen1,2, Zian Xu1,2
1School of Public Health, Fudan University, Shanghai, China.
Journal of neuro-oncology
|April 2, 2024
概括
瘤治疗场 (TTFields) 加上铁胺 (TMZ) 是新诊断的质母细胞瘤 (GBM) 的成本效益. 这种创新疗法可以提高生存率和生活质量,使其成为一种有价值的治疗选择.
科学领域:
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
- 医疗技术 医疗技术 医学技术
背景情况:
- 质母细胞瘤 (GBM) 是一种具有有限治疗选择的侵袭性脑癌.
- 结合化疗的瘤治疗场 (TTFields) 显示出改善患者结果的希望.
- 在对TTFields对GBM的健康经济评估中存在很大的差距.
研究的目的:
- 为了评估TTFields加temozolomide (TMZ) 与单独的TMZ对新诊断的GBM的成本效益.
- 提供经济证据,为GBM治疗的知情政策制定提供经济证据.
主要方法:
- 一个分区的生存模型估计了终身成本和质量调整后生命年 (QALYs).
- 利用了来自现实研究,临床试验 (EF-14) 和文献的数据.
- 对成本效益的评估是根据CN¥242,928/QALY的支付意愿值进行评估.
主要成果:
- TTFields + TMZ增加了389,326元的成本,并获得了2.46个QALY.
- 增量成本效益比率 (ICER) 为每QALY157,979日元.
- 在指定值时,TTFields + TMZ具有成本效益的概率为95.60%.
结论:
- 将TTFields纳入TMZ治疗GBM是一种具有成本效益的策略.
- 这些发现支持TTFields作为GBM治疗方案的宝贵补充.
- 经济证据支持在GBM的临床实践中采用TTFields.
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