跨性别男性可以通过低剂量丸激素治疗来实现足够的肌肉发育:关于身体组成变化的长期研究
Yusuke Tominaga1, Tomoko Kobayashi1, Yuko Matsumoto2
1Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Andrology
|April 2, 2024
概括
用丸激素进行性别肯定激素治疗 (GAHT) 对跨性别男性来说是安全有效的. 低剂量有效增加瘦体质量 (LBM),而高剂量可以加速肌肉增长,没有不良影响.
科学领域:
- 内分泌学 在内分泌学.
- 跨性别者健康 跨性别者健康
- 男人的健康 男人的健康
背景情况:
- 性别肯定激素治疗 (GAHT) 对于变性人来说至关重要,他们需要将身体特征与性别认同保持一致.
- 对GAHT的长期安全性和有效性数据,特别是对跨性别男性的丸激素治疗,仍然有限.
研究的目的:
- 评估丸激素治疗对跨性别男性的长期身体影响和安全性.
- 评估不同剂量的丸激素对身体结果和实验室参数的影响.
主要方法:
- 在2000年5月至2021年12月期间,对2000年5月至2021年12月间开始GAHT的跨性别男性进行回顾性分析.
- 收集了关于身体成分 (BMI,体脂百分比,瘦身量),握力,血液标记物和月经停止的数据.
- 低剂量 (≤62.5毫克/周) 与高剂量 (>62.5毫克/周) 疗法进行比较.
主要成果:
- 在12个月内,低剂量和高剂量组之间的月经停止率没有显著差异.
- 这两组在第一年体验了体脂减少和肌肉质增加,长期略有增加.
- 高剂量组显示出更大的初始瘦肉体质量增长;高剂量与3个月和6个月的LBM增加相关.
- 没有观察到长期的剂量依赖性不良反应,如多细胞血症或失脂血症.
结论:
- 长期使用的GAHT对跨性别男性来说是安全有效的.
- 低剂量的丸激素足以实现瘦体质量的增加.
- 较高的丸激素剂量可能会加速肌肉质量发展.
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