在形成结肠第三级淋巴状组织的肠道上皮细胞中的烯碳化合物受体活性
E L Garcia-Villatoro1, A Ufondu2, E S Callaway2
1Department of Nutrition, Texas A&M University, College Station, Texas, United States.
概括
在肠道上皮细胞中,生物性别和阿里碳水化合物受体 (AhR) 表达影响了结肠中的三级淋巴组织 (TLT) 发育. 男性的AhR损失加剧了炎症,改变了TLT的组成,与女性不同.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 结肠中的二次淋巴组织 (SLT) 发育取决于免疫细胞中的酸受体 (AhR).
- 三级淋巴组织 (TLTs) 在炎症部位形成,对结肠的适应性免疫至关重要.
- 肠上皮细胞 (IEC) 中的AhR对TLT发展的作用基本上是未知的.
研究的目的:
- 研究IEC中条件AhR损失对TLT形成和急性炎症期间免疫细胞组成的影响.
- 探索TLT发展和疾病结果的性别特异性差异.
主要方法:
- 在IEC中使用了一种有条件丧失AhR的小鼠模型.
- 使用德克斯硫酸盐 (DSS) 诱导的急性结肠炎.
- 分析了TLT形成,免疫细胞组成,疾病活性和肠道微生物种群.
主要成果:
- 在女性中,IEC AhR的丧失减少了TLT的形成,但没有改变疾病的结果.
- 在男性中,IEC AhR的丧失增加了疾病活性,TLT数量和T细胞密度,同时降低了B-T细胞比率.
- 性别和IEC AhR状态影响了肠道微生物组成.
结论:
- 结肠TLT形成受到生物性别和IECs中的AhR表达的影响.
- 在临床前模型中,IEC AhR的丧失对炎症和TLT发展具有性别特异性影响.
- 这些发现强调了性别和IEC AhR在肠道免疫和炎症反应中的重要性.
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