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Updated: Jun 29, 2025

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在双胞胎怀孕的早产新生儿中,甲状腺功能的参考间隔从第五到第七天:一项为期8年的回顾性研究
Xin-Ting Zheng1, Xin Lin1, Mei Ma2
1Department of neonatology, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical University, Daoshan Road 18th, Gulou Strict, Fuzhou City, Fujian Province, 350001, China.
概括
这项研究建立了双胞胎新生儿甲状腺功能的第一个参考间隔,有助于诊断诸如先天性甲状腺功能低下等疾病. 结果详细介绍了自由甲状腺素 (FT4),自由三甲状腺素 (FT3) 和甲状腺刺激激素 (TSH) 水平,按妊娠年龄和性别划分.
科学领域:
- 新生儿内分泌学 新生儿内分泌学
- 甲状腺功能测试测试甲状腺功能测试
- 双胞胎研究是关于双胞胎的研究.
背景情况:
- 下垂体-垂体-甲状腺轴在产后成熟,导致新生儿的甲状腺激素水平变化.
- 对于双胞胎新生儿,没有建立的甲状腺功能测试 (自由甲状腺素,自由三甲状腺素,甲状腺刺激激素) 的参考间隔.
- 准确的参考间隔对于在这个特定人群中诊断甲状腺功能障碍至关重要.
研究的目的:
- 建立双胞胎新生儿甲状腺功能测试的参考间隔.
- 分析基于双胞胎妊娠年龄和性别的甲状腺功能变化.
- 为双胞胎婴儿甲状腺健康的临床评估提供基础标准.
主要方法:
- 从273对双胞胎新生儿 (2015-2022) 中收集了甲状腺功能数据 (FT4,FT3,TSH).
- 每对新生儿分为"新生儿A" (出生时体重较高) 和"新生儿B" (出生时体重较低).
- 根据妊娠年龄 (26-36周) 和性别分析和比较参考间隔.
主要成果:
- 在双胞胎新生儿 (GA 26-36周) 中确定FT3,FT4和TSH的参考间隔.
- 在不同妊娠年龄 (p < 0.05) 中观察到FT3和FT4参考间隔的显著差异.
- 男性新生儿的FT3和FT4参考间隔比29-32周妊娠年龄组的女性更低 (p <0.05).
结论:
- 本研究介绍了双胞胎新生儿甲状腺功能的第一个参考间隔,在生命的第5到第7天.
- 这些确定的间隔对于改善双胞胎先天性甲状腺功能低下症的诊断和管理至关重要.
- 这些发现凸显了对双胞胎特定参考范围的需求,因为受妊娠年龄和性别影响的变化.
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