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在新型葡萄球菌盒染色体中编码的 Staphylococcus pseudintermedius 中存在甲素耐药性 mec (SCCmec) 变体

A C MacFadyen¹, G K Paterson¹

¹Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.

The Journal of antimicrobial chemotherapy

|April 2, 2024

概括

新型移动遗传元素称为SCCmec,携带甲素耐药性基因,在狗狗中被发现. 这些发现对于了解兽医和人类医学中的抗菌素耐药性至关重要.

科学领域:

兽医微生物学兽医微生物学
分子生物学分子生物学
抗微生物耐药性研究研究

背景情况:

伪中间体葡萄球菌 (Staphylococcus pseudintermedius) 是狗中的一个重要的机会性病原体,偶尔会给人类带来风险.
抗微生物耐药性,特别是由SCCmec元素中的mecA基因介导的甲素耐药性,使治疗复杂化.
在非黄金色葡萄球菌中SCCmec元素的多样性表明S. pseudintermedius.中可能存在新型变异.

研究的目的:

描述SCCmec元素存在于四个临床隔离犬类Staphylococcus pseudintermedius的特征.
在这个重要的兽医病原体中识别和描述新的SCCmec类型.

主要方法:

在S. pseudintermedius的四个犬类临床分离物中进行全基因组测序.
从测序的基因组中组装和注释SCCmec元素.
对已识别的SCCmec元素与已知的类型进行比较分析.

主要成果:

在犬种分离物中发现了两种新的SCCmec元素.
一个新元素,SCCmec7017-61515,具有A类mec基因复合体和5型ccr的独特组合.
剩下的三个分离物中含有一种新的复合物SCCmec元素,具有SCCmec类型IV和VI的特征.

结论:

斯塔菲洛科克 (Staphylococcus pseudintermedius) 作为新型SCCmec元素的储存库.
鉴定这些新元素对理解和管理兽医和人类健康中的抗菌素耐药性有重大影响.
对这些元素的进一步研究是有必要的,以评估它们的传播和影响.

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