对于阿兹特雷诺南与阿维巴克坦联合使用的磁盘扩散方法对肠道细菌的性能
Dandan Yin1, Peipei Song1,2, Lan Jiang1,3
1Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
The Journal of antimicrobial chemotherapy
|April 2, 2024
概括
一种新的磁盘扩散方法有效地测试了阿兹特里奥纳姆-阿维巴克坦对产生卡巴酶的肠道细菌的敏感性. 这种经济的方法为临床微生物学实验室提供了实际的实用性.
科学领域:
- 临床微生物学 临床微生物学
- 抗生素敏感性测试 抗生素敏感性测试
- 传染性疾病 传染性疾病
背景情况:
- 碳酶生成肠道细菌 (CPE) 由于治疗选择有限而构成重大威胁.
- 阿兹特雷诺南与阿维巴克坦结合使用,对CPE有很大的前景.
- 准确且易于使用的敏感性测试方法对于指导治疗至关重要.
研究的目的:
- 为了评估内部开发的阿兹特雷诺姆-阿维巴克坦磁盘扩散方法的性能.
- 为了将磁盘扩散方法与参考微稀释方法进行比较.
- 为了确定磁盘扩散试验的最佳敏感性断点.
主要方法:
- 在实验室测试了204种产生碳烯酶的Enterobacteriales分离物.
- 使用30/20和10/4μg阿兹特雷诺姆/阿维巴克坦盘的磁盘扩散方法.
- 用作比较的参考标准的微稀释方法.
主要成果:
- 使用dBETs软件确定了最佳的敏感性/耐药性断点.
- 磁盘扩散方法与参考方法达成了98.0%的绝对一致.
- 在测试的磁盘度中,错误率包括0.5%的重大错误和37.5%的非常重大错误.
结论:
- 公司内部开发的磁盘扩散方法是对阿兹特雷诺姆-阿维巴克坦敏感性测试的可行替代方案.
- 该方法表现出良好的性能,具有高度的分类一致性.
- 它为临床微生物学实验室提供了一种经济实用的解决方案.
更多相关视频
12:03Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
26.2K
08:58Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
6.4K
相关概念视频
Antimicrobial Effectiveness
2.3K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2.3K
Automated Microbial Diagnostics
77
Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
77
