肠道透性与年轻人的胰岛素敏感性降低有关,这些年轻人患有围产期获得的HIV
Sahera Dirajlal-Fargo1,2, Wendy Yu3, Denise L Jacobson3
1Rainbow Babies and Children's Hospital and Case Western Reserve University, Cleveland, Ohio.
AIDS (London, England)
|April 2, 2024
概括
肠道屏障损伤,以佐努林为标志,与患有围产期获得的艾滋病毒 (YPHIV) 的年轻人胰岛素耐药性增加有关. 这表明肠道健康会影响代谢并发症,即使有病毒抑制.
科学领域:
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
- 代谢健康 代谢健康
背景情况:
- 调查肠道屏障功能障碍与患有围产期艾滋病毒 (YPHIV) 的年轻人代谢并发症之间的联系至关重要.
- 以前的研究还没有完全探索细菌转移和代谢问题在这个群体之间的关系.
研究的目的:
- 检查YPHIV.HIV中肠道屏障完整性标记物和代谢参数 (胰岛素耐药性和非高密度胆固醇) 之间的关联.
- 为了确定肠道损伤是否影响YPHIV患者的胰岛素敏感性,尽管病毒被抑制.
主要方法:
- 来自PHACS青少年主协议数据的分析,包括具有抑制HIV病毒载量的YPHIV.
- 在基线测量肠道脂肪酸结合蛋白 (I-FABP),脂多糖结合蛋白 (LBP) 和佐努林的血水平.
- 使用线性回归模型来评估肠道标志物与胰岛素耐药性 (HOMA-IR) 和非高密度胆固醇 (非高密度胆固醇) 在3年内稳定性评估的关联.
主要成果:
- 较高的原始水平的佐努林显著与增加的HOMA-IR在原始值,2年和3年.
- 升高的I-FABP显示出趋向于降低HOMA-IR的趋势.
- 桑努林在基线也与非HDLc相关,但随着时间的推移,这种关联没有持续下去.
结论:
- 肠道屏障损伤,特别是高素水平表明,与YPHIV的胰岛素敏感性受损有关.
- 这些发现强调了肠道健康在YPHIV患者经历的代谢并发症中的潜在作用,即使在有效的抗逆转录病毒疗法下也是如此.
- 需要进一步的研究来探索针对肠道屏障的治疗策略,以改善这一群体的代谢结果.
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