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Updated: Jun 29, 2025

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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中间释放的动力学增强P450 11B2-催化阿尔多的合成

Juan Valentín-Goyco1,2,3, Sang-Choul Im1,2,3, Richard J Auchus1,2,3

  • 1Division of Metabolism, Endocrinology, & Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.

Biochemistry
|April 2, 2024
PubMed
概括

细胞染色体P450 11B2 (阿尔多合成酶) 通过一个过程机制合成阿尔多. 中间解离速率,而不是NADPH合,决定了阿尔多的产生,揭示了对类固醇生物合成的关键见解.

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