氨酸改善了提拉姆诱导的小腿骨异构形和肠道微生物群异构形在 brojlers
Shimeng Zhou1, Chuxian Quan1, Zhao Zhang1
1College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, PR China.
Ecotoxicology and environmental safety
|April 2, 2024
概括
氨酸补充剂通过调节基因表达和改善肠道微生物平衡,有效地减轻肉中提拉姆诱导的小腿椎骨形 (TD). 这种饮食干预为禽类健康和经济损失提供了有希望的解决方案.
科学领域:
- 动物科学动物科学
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
背景情况:
- 一种农业化学物质 - - 蒂拉姆 (Thiram) 在肉中引起小腿骨缺血症 (tibial dyschondroplasia,TD),导致严重的经济损失.
- 了解TD的保护机制对于家禽业至关重要.
研究的目的:
- 为了研究氨酸如何减轻肉中提拉姆诱导的TD.
- 探索白对受影响鸟类肠道微生物多样性的影响.
主要方法:
- 肉被暴露在蒂拉姆中,并接受了不同度的氨酸治疗.
- 分析了骨参数,基因表达 (HIF-1α/VEGFA, Ihh/PTHrP) 和肠道微生物群组成 (16S rRNA测序).
主要成果:
- 氨酸补充改善了提拉姆诱导的TD肉的性能指标和关节参数.
- 氨酸降低了HIF-1α,VEGFA和PTHrP的表达,同时上调了Ihh的表达.
- 氨酸治疗减少了有害的肠道细菌,增加了有益的短链脂肪酸产生细菌.
结论:
- 氨酸有效地缓解了肉中提拉姆诱导的TD症状.
- 氨酸有助于恢复肠道微生物群的平衡,有助于改善家禽健康.
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