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格林调节了孕期糖尿病中内等质网膜压力信号通路的调节

Xinying Li¹, Qun Ji², Chunrong Zhong³

¹Department of Endocrinology, Guangzhou Red Cross Hospital Affiliated to Jinan University, Guangzhou, China; Medical Care Center, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.

Biochemical and biophysical research communications

|April 2, 2024

概括

格林林治疗改善了妊娠期糖尿病 (GDM) 通过抑制细胞内网膜应激 (ERS) 和小岛细胞亡. 用格林向ESR显示出作为GDM治疗策略的希望.

科学领域:

内分泌学在内分泌学.
代谢障碍代谢障碍代谢障碍
细胞生物学细胞生物学

背景情况:

孕期糖尿病 (GDM) 是一个重要的妊娠并发症.
细胞内膜网膜应激 (ERS) 与GDM病变发生有关.
格林在调节GDM中ESR中的作用尚不清楚.

研究的目的:

在GDM小鼠模型中研究格林对ERS信号传递的影响.
阐明格林通过哪些机制影响GDM中的ERS和小岛细胞功能.
评估格林素作为GDM潜在的治疗点.

主要方法:

在C57BL/6小鼠中,使用高脂肪饮食和链毒素 (STZ) 诱导了GDM.
用格林或格林抑制剂治疗小鼠,并测量生理参数.
评估了胰腺小岛形态,亡率以及与ERS相关的蛋白质/mRNA表达 (PERK,ATF6,IREIα,GRP78,CHOP,caspase-12) 的情况.

主要成果:

格林林治疗显著改善了GDM小鼠的葡萄糖耐受性,胰岛素水平,并减少了高血糖症.
格林林的使用降低了岛屿细胞的亡,并抑制了关键ERS标志物的表达.
在体外研究证实了格林能够减轻NIT-1细胞中高葡萄糖或尼胺诱导的亡和ERS的能力.

结论:

格雷林有效地抑制了GDM小鼠和胰腺β细胞的内质网膜应激和亡.
这项研究确立了 ghrelin,ERS 和 GDM 之间的显著联系.
用格林准ESR是一个有前途的治疗途径,用于管理妊娠期糖尿病.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.细胞内膜网膜应激压力孕期糖尿病是一种糖尿病.格林林 (Ghrelin) 是一种激素.

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