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从内微生物群中获得的丁酸盐促进了肺癌的转移

Yi Ma¹, Haiming Chen², Haoran Li²

¹Department of Thoracic Surgery, Thoracic Oncology Institute, Peking University People's Hospital, Beijing 100044, China; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Shanghai 200433, China.

Cell reports. Medicine

|April 2, 2024

概括

肺癌 (LC) 复发与较低的内微生物群多样性和丰富的酸盐生产细菌有关. 这种肠道微生物群的特征预测了LC的复发,并促进了转移,提供了新的治疗点.

科学领域:

在瘤学瘤学.
微生物组研究微生物组研究
癌症转移癌症转移

背景情况:

肺癌 (LC) 术后复发通常发生在三年内,但机制尚未完全理解.
瘤内微生物组在LC进展和复发中的作用仍然是积极研究的领域.

研究的目的:

研究内微生物组与肺癌复发之间的关系.
识别可以预测LC复发和转移的微生物特征.
阐明内细菌,宿主基因表达和癌症进展之间的机械联系.

主要方法:

来自LC患者的内组织的16SrRNA基因测序,具有不同的无复发生存时间.
对循环微生物组DNA进行分析,以预测潜力.
在体内实验涉及内注射细菌和瘤生长评估.
分子分析包括基因表达,基因素乙化和巨细胞极化研究.

主要成果:

与非复发组相比,LC复发组中的瘤内微生物群多样性明显较低.
产生丁酸盐的细菌,如Roseburia,在复发组中得到了丰富.
内微生物组特征和循环微生物组DNA在预测LC复发方面表现得精确.
细菌衍生的酸盐通过通过HDAC2抑制和M2巨细胞极化通过上调H19表达来促进LC转移.

结论:

内微生物组在肺癌复发和转移中起着至关重要的作用.
瘤和循环中的微生物特征对LC具有预后价值.
向瘤内微生物组及其代谢物是管理LC复发和转移的潜在治疗策略.

关键词:

黄油酸盐黄油酸盐是一种肺癌是一种肺癌.巨细胞是一个巨细胞.转移转移转移转移微生物组是一个微生物组.复发性复发性复发性

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