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Updated: Jun 29, 2025

Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations
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在MYC-FBW7 phosphodegron的生殖点突变启动了造血性恶性瘤

Brian Freie1, Patrick A Carroll2, Barbara J Varnum-Finney3

  • 1Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA; eisenman@fredhutch.org bfreie@fredhutch.org.

Genes & development
|April 2, 2024
PubMed
概括

一个单一的MYC变基因突变 (T58A) 稳定了MYC蛋白质,导致了造血祖先的异常自我更新. 这种功能增益突变促进了小鼠的淋巴瘤和白血病的发展.

关键词:
FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FBW7FB我的世界 MYC血液形成 血液形成这种白血病是白血病.淋巴瘤淋巴瘤是什么原始细胞是原始细胞.蛋白质的稳定性 蛋白质的稳定性它是自我更新的.

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