在下丘脑副腹腔核中的GLP-1促进了交感激活和高血压
Xiao-Yu Xu1, Jing-Xiao Wang1, Jun-Liu Chen1
1Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, and Department of Physiology, Nanjing Medical University, Nanjing 211166, China.
类似葡萄糖类-1受体 (GLP-1R) 在副腹腔核中的激活会增加交感神经活动和血压. 在副腹腔核中升级的GLP-1R通过增强氧化应激会导致高血压.
科学领域:
- 神经科学是一个神经科学.
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
背景情况:
- 葡萄糖类-1 (GLP-1) 的类似物用于糖尿病. 副腹腔核 (PVN) 调节心血管活动.
- GLP-1及其受体 (GLP-1R) 在PVN对交感外流和血压的控制中的作用尚未完全理解.
研究的目的:
- 研究GLP-1R在PVN中对交感活动和血压的作用.
- 探索涉及GLP-1R介导心血管调节的潜在信号通路.
- 检查GLP-1和GLP-1R在自发高血压大鼠 (SHR) 的PVN中的参与.
主要方法:
- 实验是在雄性常压大鼠和SHR中进行的.
- 测量包括交感神经活动 (RSNA) 和平均动脉压 (MAP).
- 微注射到PVN涉及GLP-1R激动剂/对抗剂,抗氧化剂和信号通路抑制剂.
主要成果:
- 在PVN中的GLP-1R激活通过cAMP-PKA介导的NADPH氧化酶激活和超氧化物产生增加了RSNA和MAP.
- 在SHR的PVN中,GLP-1和GLP-1R被上调.
- 在SHR中,PVN GLP-1R激活加剧了高血压,而对抗剂在SHR中表现出比正常血压大鼠更大的效果.
结论:
- 在PVN中GLP-1R的激活增强了交感外流和血压.
- 这些效应的介导者是cAMP-PKA-NADPH氧化酶-超氧化物通路.
- 在PVN中GLP-1和GLP-1R的上调有助于SHR中的交感性过活和高血压.
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