在UDP-Glucuronosyltransferase (UGT) 1A第一个外因子区域内激活隐秘的捐赠者拼接位会产生编码UGT1A蛋白质的变异性转录,这些变异性转录具有截断的甘结合域

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Updated: Jun 29, 2025

A Reporter Based Cellular Assay for Monitoring Splicing Efficiency
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A Reporter Based Cellular Assay for Monitoring Splicing Efficiency

Published on: September 15, 2021

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Dong Gui Hu1, Shashikanth Marri2, Julie-Ann Hulin2

  • 1College of Medicine and Public Health, Flinders Health and Medical Research Institute Flinders University, Bedford Park, Australia donggui.hu@flinders.edu.au.

Drug metabolism and disposition: the biological fate of chemicals
|April 2, 2024
PubMed
概括

发现了新型的UDP-glucuronosyltransferase (UGT) 1A变体,这些变体来自隐秘的拼接部位. 1A8_n2变异在结直肠组织中非常丰富,可能通过葡萄糖化影响药物代谢.

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