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饮食乳化剂聚酸盐80暴露加速与年龄相关的认知衰退

Lan Zhang¹, Zhenyu Yin¹, Xilei Liu²

¹Haihe Laboratory of Cell Ecosystem, Department of Geriatrics, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Geriatrics Institute, Tianjin Medical University General Hospital, Tianjin, China.

Brain, behavior, and immunity

|April 2, 2024

概括

食品添加剂聚酸盐80 (P80) 通过破坏肠道微生物群和肠-大脑轴,加速老年小鼠的认知衰退. 这种乳化剂促进神经炎症,可能是与年龄有关的认知障碍的危险因素.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
老年学是一门学科.

背景情况:

肠道微生物平衡对于老年人的认知健康至关重要.
聚酸盐80 (P80),一种常见的食品乳化剂,改变了肠道微生物群.
长期暴露于P80对通过肠-大脑轴的年龄相关认知衰退的影响尚不清楚.

研究的目的:

研究P80对肠道微生物群和老年小鼠认知功能的影响.
阐明P80影响肠-大脑轴和认知健康的机制.

主要方法:

利用衰老加速小鼠易患8 (SAMP8) 类小鼠,这是加速衰老的模型.
服用P80 (1%在饮用水中) 持续12周.
评估认知功能,大脑病理,血脑屏障完整性,肠道微生物组合和胆酸代谢.

主要成果:

在SAMP8小鼠中,P80的摄入加剧了认知衰退,增加了脑病态蛋白,破坏了血脑屏障,并激活了神经炎症.
P80诱导了肠道失调,增加了产生二次胆汁酸的细菌,如鲁米诺可可科科,拉克诺斯皮拉科和克洛斯特里迪亚斯辛登斯.
来自暴露于P80的小鼠的便微生物群移植在接受者小鼠中恶化了认知衰退和肠道屏障损伤.
暴露于P80增加了脱氧醇酸 (DCA) 水平,它激活了微质,并通过ABCA1-介导的胆固醇进口促进了与衰老相关的分泌表型.

结论:

乳化剂P80加速了老年小鼠的认知衰退.
P80通过肠道失调,改变胆酸代谢,破坏肠道和血脑屏障以及神经炎症诱导认知衰退.
饮食P80诱导的肠道微生物群失调是一种与年龄相关的认知衰退的潜在危险因素.

关键词:

与年龄相关的认知能力下降脱氧胆酸是一种脱氧胆酸.乳化剂是一种乳化剂.我们的肠道微生物群.肠-大脑轴肠-大脑轴神经炎症是一种神经炎症.

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