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黄 (Sarcandra glabra,Thunb.) 是一种的植物. 纳卡伊通过促进恢复,恢复屏障功能,调节肠细胞中的IL-17/Notch1/FoxP3通路来缓解DSS诱导的性结肠炎

Shuling Zhang¹, Yanwu Li², Gang Chen³

¹Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.

Journal of ethnopharmacology

|April 2, 2024

概括

白 (Zhong Jie Feng) 通过促进肠道愈合和平衡免疫反应,有效治疗实验性性结肠炎. 这种传统医学在缓解结肠炎症状和恢复肠道健康方面显示出潜力.

科学领域:

植物化学和药理学
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

黄 (Zhong Jie Feng) 是一种用于消化和肠道疾病的传统药物.
它在实验性性结肠炎 (UC) 中的治疗作用和机制在很大程度上仍未被探索.

研究的目的:

在实验性性结肠炎模型中研究Sarcandra glabra (ZJF) 的疗效和潜在机制.
为了分析S. glabra水提取物的化学成分.

主要方法:

使用UPLC-MS/MS.进行ZJF的化学分析.
肠道细胞增殖和抗炎作用的体外评估.
在DSS诱导的大肠炎模型中的体内评估,用梅萨拉作为阳性对照.
结肠基因表达的分析,蛋白质水平,紧密的结节,细胞亡和免疫细胞的形状.

主要成果:

ZJF显示大肠炎症状显著缓解,与梅萨拉可比.
它促进了结肠上皮细胞的增殖和恢复.
ZJF抑制了促炎性细胞因子,调节了M1/M2巨细胞比率,并减少了亡.
它恢复了紧结蛋白水平,并影响了IL-17/Notch1/FoxP3通路.

结论:

在实验UC中,Sarcandra glabra促进了肠道恢复和免疫平衡.
IL-17/Notch1/FoxP3通路是ZJF治疗效果的一个关键目标.
这些发现支持使用S. glabra治疗性结肠炎.

关键词:

IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD 它的IL-17是IL-17.标记1 标记1 标记斯·格拉布拉 (S. glabra) 是一个可怕的动物.这就是为什么UCUCUCUC.

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