针对糖尿病病中的代谢相关脂肪肝疾病:呼吁采取行动
Salvador Benlloch1, Francesc Moncho2, Jose Luis Górriz3
1Servicio de Digestivo, Hospital Arnau de Vilanova, Universidad CEU-Cardenal Herrera, Valencia, CIBERhed-Instituto de salud Carlos III, Madrid, Spain.
Nefrologia
|April 2, 2024
概括
与代谢相关的脂肪肝疾病 (MAFLD) 在2型糖尿病 (T2DM) 患者中很常见,增加心血管和脏疾病的风险. 针对MAFLD可能会改善糖尿病病患者的治疗结果.
科学领域:
- 肝病学和代谢疾病
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 非酒精性脂肪性肝病,现在称为代谢相关脂肪性肝病 (MAFLD),越来越普遍,特别是在2型糖尿病患者中.
- 患有MAFLD和T2DM的患者患心血管疾病 (CVD) 和慢性病 (CKD),特别是糖尿病病的风险显著增加.
- MAFLD,CVD,CKD和T2DM在肝心脏代谢轴中具有共同的病理生理基础.
研究的目的:
- 审查MAFLD,CVD,CKD和T2DM之间的多方向临床关系.
- 强调在糖尿病病的背景下解决MAFLD的重要性.
- 强调早期检测高风险患者,以改善预后.
主要方法:
- 文献综述侧重于MAFLD,T2DM,CVD和CKD之间的相互作用.
- 对共享的病理生理机制的分析.
- 强调临床影响和治疗向.
主要成果:
- MAFLD可以先于心血管疾病和CKD的发展.
- MAFLD可以加剧现有的心血管疾病和CKD的预后.
- 这些情况之间存在着明确的,多方向的临床关系.
结论:
- 在T2DM患者中,MAFLD是心血管疾病和CKD进展的关键因素.
- 针对MAFLD对于治疗糖尿病病患者至关重要.
- 在高危MAFLD患者的早期鉴定和干预可以改善整体预后.
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