相关实验视频
Updated: Jun 29, 2025

07:09
Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
36.2K
与肥胖相关的T细胞功能障碍会损害免疫监测,增加癌症风险
Alexander Piening1, Emily Ebert1, Carter Gottlieb1
1Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Nature communications
|April 2, 2024
概括
肥胖会影响免疫监测,增加癌症风险. 通过饮食减肥,而不是塞马格卢提德,恢复了T细胞功能,影响了癌症免疫治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 代谢性疾病是一种代谢性疾病.
背景情况:
- 肥胖是已知的癌症风险因素,但涉及免疫功能障碍的机制尚未完全理解.
- 肥胖对抗瘤免疫反应和癌症易感性的影响需要进一步研究.
- 了解肥胖与癌症的联系对于改善患者的治疗结果至关重要,特别是在免疫疗法环境中.
研究的目的:
- 研究肥胖和减肥对瘤中CD8+T细胞反应的影响.
- 为了确定饮食限制或塞马格卢提德治疗是否对免疫功能和癌症发展产生差异性影响.
- 阐明免疫功能障碍在肥胖相关癌症中的作用及其对免疫疗法的敏感性.
主要方法:
- 利用一种由饮食引起的肥胖症的小鼠模型.
- 在瘦肉,肥胖和体重减轻 (饮食或半谷氨酸) 的小鼠中评估瘤透的CD8+T细胞反应.
- 评估了化学致癌物暴露后的肉瘤发育和瘤免疫性.
- 在不同代谢状态下对免疫治疗的检查反应.
主要成果:
- 饮食干预,与塞马格卢提德不同,恢复了CD8+T细胞功能,并改善了肥胖小鼠的免疫治疗反应.
- 肥胖导致了由免疫功能障碍导致的瘤发病率增加.
- 尽管免疫监测受损,但肥胖增强了瘤免疫性,增加了对免疫治疗的敏感性.
结论:
- 与肥胖相关的免疫功能障碍有助于癌症易感性.
- 饮食干预可以恢复抗瘤免疫力,而西马格卢提德不能.
- 肥胖,免疫和癌症之间的复杂相互作用解释了免疫治疗中的"肥胖悖论".
相关概念视频
Psychoneuroimmunology: Diabetes and Cancer
28
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
28
Obesity
498
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
498
Tumor Immunotherapy
523
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
523
T Cell Activation and Clonal Selection
721
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
721
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K

