相关实验视频

Updated: Jun 29, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

在有固体瘤的患者中对Trop2的免疫PET成像

Wei Huang¹, You Zhang¹, Min Cao²

¹Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Rd, Shanghai, 200127, China.

EMBO molecular medicine

|April 2, 2024

概括

研究人员开发了一种新的[68Ga]Ga-NOTA-T4追踪器,用于成像热细胞表面抗原2 (Trop2) 表达. 这种新工具有助于选择和监测针对癌症向治疗的患者.

科学领域:

在瘤学瘤学.
放射化学放射化学是指辐射化学.
分子成像分子成像技术

背景情况:

精密疗法需要精确的患者选择针对性治疗.
热囊细胞表面抗原2 (Trop2) 是一种泛癌生物标志物,在瘤发生过程中至关重要.
为患者分层开发可靠的生物标志物至关重要.

研究的目的:

开发用于Trophoblast细胞表面抗原2 (Trop2) 成像的新型纳米体追踪剂.
评估[68Ga]Ga-NOTA-T4.4的药理学特性和向能力.
评估[68Ga]Ga-NOTA-T4免疫-位子发射断层扫描 (immunoPET) 在临床前和临床环境中可视化Trop2表达的实用性.

主要方法:

开发和放射性标记两个68Ga标记的纳米体追踪器,针对Trop2.
在小鼠模型和 beagle 狗中对标记剂的药理动力学的临床前评估.
在固体瘤模型和人类患者中对Trop2表达的非侵入性免疫oPET成像.

主要成果:

成功开发了两种68Ga标记的纳米体追踪器,目标是Trop2.
[68Ga]Ga-NOTA-T4在临床前研究中表现出有利的药理动力学.
使用[68Ga]Ga-NOTA-T4的免疫PET有效地可视化了前临床模型和十名患者中的瘤中异质Trop2表达.

结论:

[68Ga]Ga-NOTA-T4是一个有前途的纳米体追踪器用于Trop2成像.
使用[68Ga]Ga-NOTA-T4的免疫PET可进行Trop2表达的非侵入性评估.
这项技术可以帮助对 Trop2 向疗法进行患者分层和响应监测.

关键词:

伴侣诊断系统伴侣诊断系统免疫性PET是一种PET.一个纳米人体.热门节目热门节目热门节目热带地区热带地区

更多相关视频

Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by PET/CT

Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by PET/CT

Published on: April 29, 2017

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

Published on: February 3, 2015

相关概念视频

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...