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向瘤微环境,这是前列腺癌的新疗法

Bangwei Fang^1,2,3, Ying Lu⁴, Xiaomeng Li^1,2,3

¹Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Prostate cancer and prostatic diseases

|April 2, 2024

概括

与瘤相关的巨细胞 (TAMs),与癌症相关的纤维细胞 (CAFs) 和髓质衍生抑制细胞 (MDSCs) 是前列腺癌 (PCa) 进展和治疗耐药性的关键参与者. 准这些细胞对新的PCa疗法有希望.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

前列腺癌 (PCa) 瘤微环境 (TME) 涉及适应性免疫细胞和其他组成部分,如瘤相关的巨细胞 (TAM),癌症相关的纤维细胞 (CAF) 和髓质衍生抑制细胞 (MDSC).
这些非适应性免疫细胞越来越被认为是PCa进展的关键调节器和潜在的治疗点.

研究的目的:

审查TME内的TAM,CAF,MDSC和PCa细胞之间的相互作用机制.
总结一下目前针对PCa中这些细胞组件的治疗进展.
讨论潜在的未来治疗策略.

主要方法:

在PubMed.com上进行了全面的文献搜索.
包括到2023年12月10日发表的研究,重点关注PCa中的TAM,CAF和MDSC.

主要成果:

TAMs,CAFs和MDSCs显著影响PCa瘤发生,进展和转移.
这些细胞有助于抵抗常规PCa治疗,包括抗雄激素疗法,化疗和免疫疗法.
针对这些细胞在临床前模型和临床试验中显示出希望,但在患者选择和理解相互作用机制方面仍然存在挑战.

结论:

针对TAMs,CAFs和MDSCs为新的PCa治疗策略提供了一个有希望的途径.
需要进一步的研究来阐明特定的细胞机制,并确定新的药物点.
临床试验对于验证这些新兴治疗方法的安全性和有效性至关重要.

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