暴露于雌激素内分泌干扰剂直接影响勃起功能
Samuel M Cripps1, Sarah A Marshall2, Deidre M Mattiske1
1School of BioSciences, The University of Melbourne, Melbourne, Australia.
Communications biology
|April 2, 2024
概括
环境中的雌激素化学物质暴露,如乙乙醇 (DES),直接损害勃起组织功能,导致勃起功能障碍 (ED). 长期和短期暴露都会对勃起功能产生负面影响.
科学领域:
- 内分泌学 在内分泌学.
- 环境健康 环境健康
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 勃起功能障碍 (ED) 的患病率正在上升,这表明未知的环境因素.
- 内分泌干扰化学物质 (EDCs) 因勃起组织的荷尔蒙依赖而受到影响.
- 雌激素EDC是了解ED的环境联系的关键焦点.
研究的目的:
- 研究雌激素EDCs对勃起组织功能的直接影响.
- 模拟广泛的雌激素EDC暴露对勃起功能的影响.
- 建立雌激素EDC与ED发展之间的联系.
主要方法:
- 在雄性小鼠中,慢性暴露于雌激素EDC二甲基stilbestrol (DES).
- 评估勃起组织收缩性和全身水平.
- 在实验室内用DES和基因斯坦化分离的勃起组织.
主要成果:
- 在小鼠中,慢性DES暴露导致异常的勃起组织收缩性,表明ED.
- 暴露于DES会增加勃起组织中的雌激素受体α (Esr1) 表达,而不会改变.
- 对DES和基尼斯的急性暴露直接降低了勃起组织的收缩性.
结论:
- 雌激素EDC直接损害勃起组织功能,独立于全身水平.
- 对雌激素EDC的慢性和急性暴露都被确定为ED的危险因素.
- 这项研究确立了雌激素EDC与勃起功能障碍之间的直接因果关系.
相关概念视频
Disorders of the Male Reproductive System
404
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
404
Menopause
157
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
157
Infertility in Males
261
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
261
Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
Male Sexual Response: Erection & Ejaculation
2.2K
Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
2.2K
Spermatogenesis
102.4K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.4K


