相关实验视频

Updated: Jun 29, 2025

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

Published on: March 25, 2016

在神经发育障碍中产前和产后的神经免疫相互作用

Eunha Kim^1,2, Jun R Huh³, Gloria B Choi⁴

¹BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea. eunha_kim@korea.ac.kr.

Nature immunology

|April 2, 2024

概括

患有神经发育障碍 (NDD) 的个体的孕产妇免疫状况和免疫表型之间存在联系. 本综述探讨了NDD背后的神经免疫机制以及潜在的缓解策略.

科学领域:

神经免疫学神经免疫学
发育神经科学的发展神经科学.
免疫学免疫学免疫学

背景情况:

免疫失调越来越被认为是神经发育障碍 (NDD) 的一个因素.
怀孕期间母亲的健康状况,包括感染和慢性炎症,会影响胎儿的神经发育.
患有NDD的个体往往表现出不同的免疫学表型.

研究的目的:

综合审查母亲免疫状况对胎儿神经发育的影响.
检查患有NDD的个体的免疫表型,并探索潜在的机制.
讨论神经免疫相互作用在NDD中的作用和潜在的治疗途径.

主要方法:

关于母亲免疫状况和NDD的研究的文献综述.
在NDD群体中分析免疫标记和疾病的分析.
检查NDD目前的小鼠模型,以了解免疫机制.

主要成果:

怀孕期间母亲的免疫失调与胎儿神经发育的改变有关.
特定的免疫相关标记物和同时发生的免疫疾病在患有NDD的个体中很普遍.
神经免疫相互作用在NDD中神经现象型的表现中发挥着关键作用.

结论:

免疫失调通过各种产前和产后机制与神经发育障碍密切相关.
了解这些神经免疫相互作用对于开发针对NDD的有针对性的干预措施至关重要.
使用先进模型进行进一步的研究可以阐明因果途径并为治疗策略提供信息.

更多相关视频

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

相关概念视频

Neurotransmitters

Neurotransmitters

Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.

Disorders of the Nervous Tissue

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...