对多发性硬化症及其相关因素的治疗模式和疾病修饰疗法的持续性
Simón Cárdenas-Robledo1,2, Laura Estefanía Arenas-Vargas3, Rubén Darío Arenas4
1Centro de Esclerosis Múltiple (CEMHUN), Departamento de Neurología, Hospital Universitario Nacional de Colombia, Calle 44 # 59-75, Bogotá, Colombia. simon.cardenas@hun.edu.co.
BMC neurology
|April 2, 2024
概括
大多数多发性硬化症患者因疾病活动而转换疾病修饰疗法 (DMT). 治疗变化受患者年龄和保险状况的影响,突出了个性化多发性硬化护理的需要.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 优化多发性硬化症 (MS) 的治疗通常需要切换疾病修饰疗法 (DMT).
- 了解DMT处方模式和转换原因至关重要,特别是在代表性不足的人群中.
研究的目的:
- 调查哥伦比亚MS队列中DMT持久性,切换原因和处方模式.
- 分析影响治疗变化的因素,并在临床实践中确定关键的DMT.
主要方法:
- 对701名确诊的多发性硬化症患者进行了回顾性观察性研究.
- 卡普兰-梅尔生存分析药物持续性; 考克斯对治疗变化相关因素的比例风险模型.
- 网络分析以绘制DMT处方模式和影响的地图.
主要成果:
- 39.5%的患者保持了初始的DMT; 60.5%的患者至少换了一次,每患者/年发生率为1.09次变化.
- 转换的主要原因是MS疾病的活动 (56.7%的复发,18.6%的MRI活动),不良事件 (15.3%) 和残疾进展 (11.1%).
- 较年轻的发病年龄,治疗中心和保险公司的地位是改变治疗的重要决定因素.
结论:
- 大多数多发性硬化症患者转换DMT,主要是由疾病活动驱动的.
- 治疗决策与患者人口统计学 (如年龄) 和社会经济因素 (如保险公司地位) 有关.
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