EP300-ZNF384对IL3RA进行交换激活,以促进B细胞急性淋巴细胞白血病的进展

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Zhijie Hou1,2,3,4, Yifei Ren5,6,7, Xuehong Zhang8

  • 1Department of Hematology, Liaoning Medical Center for Hematopoietic Stem Cell Transplantation, the Second Hospital of Dalian Medical University, Dalian, 116027, China. houzhijie_818@126.com.

Cell communication and signaling : CCS
|April 2, 2024
PubMed
概括

在EP300-ZNF384融合驱动B细胞急性淋巴细胞白血病 (B-ALL) 通过增加IL3RA (CD123) 表达. 针对CD123为B-ALL患者提供了一个潜在的治疗策略.

关键词:
B细胞急性淋巴细胞白血病.在 EP300-ZNF384 中,EP300-ZNF384 是一个简单的代码.在IL-3中,IL-3被认为是IL-3.这就是IL3RA.这是白血病的产生.

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