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ATF6支持瘤细胞中的溶酶体功能,使ER应激激活的宏自和CMA:对突变TP53表达的影响

Rossella Benedetti1, Maria Anele Romeo1, Andrea Arena1

  • 1Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.

Autophagy
|April 3, 2024
PubMed
概括

抑制未折叠蛋白质响应 (UPR) 传感器ATF6具有悖论的拯救突变TP53在癌细胞中通过扰乱 lysosomal 降解. 这表明,针对ATF6对野生型TP53癌症有希望,但需要对突变TP53瘤保持谨慎.

关键词:
在ATF6中使用ATF6.在CMA,CMA是CMA.通过UPR进行全日制检查.卡特赫普辛斯 (cathepsins) 的意思是说突变TP53的发生者是TP53.这就是Thapsigargin.

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