社会认知区分了行为变体前性痴呆症的表样综合征与行为变体前性痴呆症的表样综合征
Marie-Paule E van Engelen1,2, Paulette Louwers1,2, Jay L P Fieldhouse1,2
1Alzheimer Centre Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
概括
从早期的bvFTD区分行为变异前性痴呆症 (bvFTD) 形综合征 (phFTD) 是一个挑战. 社会认知测试,特别是面部情绪识别,为区分这些疾病提供了最高的诊断准确性.
科学领域:
- 神经学 神经学
- 神经心理学 神经心理学
- 精神病学是一个精神病学.
背景情况:
- 前性痴呆症 (bvFTD) 的行为变异及其表样综合征 (phFTD) 具有共同的临床特征,使早期诊断复杂化.
- 患有phFTD的患者表现出bvFTD类症状,没有神经影像异常或疾病进展.
研究的目的:
- 评估临床医生评级,自我报告和护理人员报告的症状在区分phFTD和bvFTD的诊断效用.
- 为了确定特定的症状和测试,可以准确地区分phFTD和早期bvFTD.
主要方法:
- 该研究包括33名phFTD和95名可能的bvFTD患者.
- 评估了社会认知,行为,情绪和日常生活活动 (ADL),使用临床医生评估,自我报告和护理人员报告的措施.
- 使用后勤回归和接收器操作特征 (ROC) 曲线分析来评估诊断准确性.
主要成果:
- 面部情绪识别显示了区分phFTD和bvFTD的最高诊断准确度 (AUC0.813).
- 抑郁症状也显示出显著的诊断价值 (AUC 0.769).
- 与临床医生/自我报告相比,护理人员报告显示phFTD与bvFTD相比,在phFTD中行为和ADL损伤更大.
结论:
- 社会认知评估对于区分phFTD和bvFTD非常有效.
- 在phFTD中,护理人员报告的症状和临床医生/自我报告的数据之间存在差异.
- 需要进一步的研究来了解phFTD病因和报告差异的原因.
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