与克罗恩病相关的大脑的形态和区域自发功能异常:系统性审查和基于坐标的元分析
Ning Kong1,2, Feini Zhou1,2, Fan Zhang1,2,3
1Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China.
Cerebral cortex (New York, N.Y. : 1991)
|April 3, 2024
概括
神经成像揭示了克罗恩病患者的大脑变化. 缓解期患者显示灰质体积减少和区域同质性改变,可能与腹痛和焦虑等症状有关.
科学领域:
- 神经成像是一种神经成像.
- 胃肠病学 胃肠病学
- 神经学 神经学
背景情况:
- 克罗恩病被认为是一种大脑肠道疾病.
- 它的潜在病理生理学仍然不完全理解.
- 识别神经成像生物标志物对于理解疾病机制至关重要.
研究的目的:
- 为了确定克罗恩病的潜在神经成像生物标志物.
- 研究克罗恩病患者大脑结构和功能变化的研究.
- 为了将神经成像发现与临床表现相关联.
主要方法:
- 使用激活概率估计和以种子为基础的d映射,并对主体图像进行 permutation.
- 分析了灰色物质体积,皮质厚度,低频波动的幅度和区域均性.
- 包括健康的对照组和缓解期的克罗恩病患者.
主要成果:
- 与对照组相比,克罗恩氏病患者表现出中枢前回形中灰质体积的减少和区域均性的增加.
- 在其他前沿和岛屿地区观察到灰色物质体积和区域均性的进一步减少.
- 超回归显示了区域同质性和患者年龄之间的相关性,以及灰质变化和焦虑评分.
结论:
- 神经成像显示,克罗恩病患者的灰质体积显著减少,区域同质性发生变化.
- 这些大脑异常可能与诸如腹痛和精神疾病等临床症状有关.
- 这些发现表明了潜在的补偿机制,并突出了克罗恩病中大脑-肠轴.
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