开发和验证阴茎癌存活率的诺姆图:基于SEER和中国数据的综合研究
Jiawen Luo1,2, Jintao Hu1,2, Yelisudan Mulati1,2
1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Cancer medicine
|April 3, 2024
概括
这项研究使用SEER和中国数据开发了一种阴茎癌名谱,在预测整体存活率 (OS) 和改善临床决策方面表现优于TNM分期.
科学领域:
- 在瘤学瘤学.
- 医学统计 医学统计
- 癌症研究 癌症研究
背景情况:
- 阴茎癌研究和临床指导方针有限.
- 准确的预后工具对于患者管理至关重要.
研究的目的:
- 开发和验证用于预测阴茎癌患者的整体存活率 (OS) 的名图.
- 为了比较Nomogram与TNM分期系统的疗效.
主要方法:
- 利用来自监测,流行病学和最终结果 (SEER) 数据库的5744名阴茎癌患者 (2004-2019) 和来自中国机构的103名患者的数据.
- 使用回归分析,一致性指数 (c-index) 和决策曲线分析构建和验证了一个名ogram.
- 与TNM分阶段模型相比较的诺姆图表性能.
主要成果:
- 确定了九个独立的风险因素:年龄,种族,婚姻状况,瘤等级,组织学,TNM阶段和手术方法.
- 在内部和外部验证队列中,名图显示出强大的预测准确性 (c指数>0.73) 和临床相关性.
- 在预测效率方面,名图显著优于TNM分期系统.
结论:
- 这项研究提出了第一个用SEER数据和机构记录验证的阴茎癌预后名录.
- 与TNM阶段测定相比,开发的诺米图作为预测阴茎癌预后的卓越工具.
- 这些发现增强了管理阴茎癌患者的外科医生的临床决策.
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