在慢性髓性白血病病例中双边突然不可逆转的听力损失:一个病例报告
Hafiz Malhan1, Enas Dammag1, Waiel Alkahiry1
1Department of Adult Hematology, Prince Mohammed bin Nasser Hospital, 2034 King Abdul Aziz Rd, Jazan, 82943 Saudi Arabia.
概括
本案例研究突出了一个罕见的慢性髓性白血病 (CML) 病例,呈现出显著的听力损失. 虽然氨酸激酶抑制剂改善了CML标记物,但患者
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性髓性白血病 (CML) 是一种由BCR-ABL融合基因特征的骨髓增殖性瘤,导致过度不成熟的白细胞产生.
- 慢性慢性ML很少影响青少年,通常表现为宪法症状或偶然发现.
- 听力障碍,耳和头是不常见的CML的初始表现.
研究的目的:
- 报告一个罕见的CML病例,在一个年轻的成年女性中呈现双边听力障碍,耳和头.
- 讨论将CML与神经感官听力损失联系在一起的潜在机制.
- 评估标准CML治疗对听觉症状的影响.
主要方法:
- 一个30岁的女性突然出现听力损失的案例研究.
- 诊断工作包括全血细胞计,BCR-ABL量化和骨髓吸收.
- 治疗涉及铁激酶抑制剂 (TKIs),特别是伊马替尼.
主要成果:
- 该患者的CML诊断是基于超白细胞瘤,BCR-ABL量度为85%,以及骨髓发现.
- 伊马替尼治疗使血液学参数正常化,并降低了BCR-ABL水平.
- 尽管接受了治疗,但患者的听力损失仍然存在,需要使用助听器.
结论:
- 随着听力损失出现的CML是一个非常罕见的临床场景.
- 内耳的白血病细胞透或微血管并发症是假设的原因.
- 虽然TKI在血液学上有效地管理CML,但它们在逆转CML相关听力损失方面的有效性仍然不确定.
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