在PRRSV-1感染期间的肺病理现场
Inés Ruedas-Torres1,2, José María Sánchez-Carvajal2, Francisco Javier Salguero1
1United Kingdom Health Security Agency (UKHSA Porton Down), Salisbury, United Kingdom.
Frontiers in veterinary science
|April 3, 2024
概括
猪生殖和呼吸系统综合征 (PRRS) 在全球猪产业造成重大经济损失. 本综述详细介绍了不同PRRS病毒菌株如何影响肺病理和炎症反应.
科学领域:
- 兽医病理学 兽医病理学
- 传染性疾病 传染性疾病
- 分子生物学分子生物学
背景情况:
- 猪生殖和呼吸系统综合征 (PRRS) 是全球主要的猪病.
- 自1987年以来,世界各地发生了高度毒性菌株的爆发.
- PRRS肺部病变的范围从间歇性肺炎到严重的死形式.
研究的目的:
- 在猪肺中审查PRRS病毒1型 (PRRSV-1) 的病理学.
- 调查PRRSV菌株与肺损伤模式之间的相关性.
- 了解病毒与宿主相互作用对炎症反应的调节.
主要方法:
- 对宏观,微观和分子肺病理学发现的审查.
- 对PRRSV-1菌株特征和毒性进行分析.
- 检查受PRRS影响的肺部宿主炎症反应.
主要成果:
- PRRS肺部病理有所不同,间歇性肺炎是其标志.
- 高度毒性菌株可以诱导,增殖和死性肺炎.
- 应变毒性会影响肺炎的严重程度和类型.
结论:
- PRRSV菌株的变异影响肺病变的发展和炎症概况.
- 了解这些差异对于管理PRRS爆发至关重要.
- 对病毒与宿主相互作用的进一步研究可以阐明疾病的病原性.
相关概念视频
Pneumonia II: Pathophysiology
262
The pathophysiology of pneumonia involves the following steps:
262
Pneumonia I: Introduction
233
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
233
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
Pneumonia III: Complications and Assessment
206
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
206
Pulmonary Tuberculosis II
228
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
228


