塞尔德克斯甲基化物/德克斯甲基化物治疗注意力缺陷/多动症儿童:从实验室课堂研究中优化剂量
Andrew J Cutler1,2, Scott H Kollins3,4, Matthew N Brams5
1State University of New York (SUNY) Upstate Medical University, Syracuse, NY, United States.
优化剂量的serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) 显著改善了儿童的多动症症状. 观察到高响应率,表明对注意力缺陷/多动障碍的有效治疗.
科学领域:
- 药理学 药理学是指药理学的学科.
- 儿童精神病学 儿童精神病学
- 临床试验 临床试验
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是儿童常见的一种神经发育障碍.
- 有效的药物治疗对于管理ADHD症状和改善生活质量至关重要.
- 优化兴奋剂剂量对于最大限度地提高治疗效益,同时最大限度地减少副作用至关重要.
研究的目的:
- 根据优化的serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) 剂量来评估治疗响应率.
- 评估ADHD严重程度的变化,使用注意力缺陷/多动障碍评级尺度-5 (ADHD-RS-5) 和康纳斯第三版-家长分数.
- 确定SDX/d-MPH在患有多动症的6-12岁儿童中的疗效.
主要方法:
- 对155名儿科患者进行了21天的剂量优化阶段.
- 患者被定位到SDX/d-MPH的最佳剂量 (26.1/5.2毫克,39.2/7.8毫克或52.3/10.4毫克).
- 响应率被定义为30%和50%的ADHD-RS-5得分减少;使用康纳斯第三版-家长得分评估ADHD严重程度.
主要成果:
- 在优化剂量组中实现了高响应率 (≥50%),最高可达81.2%的响应在21.日39.2/7.8mg时.
- 与基线相比,在康纳斯第三版-家长分数的所有子尺度中观察到ADHD严重程度的显著改善.
- 优化的SDX/d-MPH剂量在减少ADHD症状方面显示出临床疗效.
结论:
- 优化SDX/d-MPH的剂量导致ADHD儿童的高治疗反应率.
- SDX/d-MPH有效地降低了ADHD症状的严重程度.
- 对SDX/d-MPH最佳剂量方案的进一步研究可以增强儿童群体的ADHD治疗策略.
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