肥胖的内脏脂肪树突细胞通过IL-33降低调控性T细胞的发育
Shindy Soedono1,2, Sharlene Sharlene1,2, Dan Hoang Nguyet Vo1,2
1Department of Integrated Biomedical Science, Soonchunhyang University, Cheonan, Republic of Korea.
Frontiers in immunology
|April 3, 2024
概括
肥胖会减少内脏脂肪中的调节性T细胞 (Tregs). 肥胖的内脏脂肪组织树突细胞 (DCs) 通过降低IL-33而损害Treg功能和分化,影响与肥胖相关的炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢性疾病研究研究.
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 在内脏脂肪组织 (VAT) 中的调节性T细胞 (Tregs) 对于管理与肥胖相关的炎症和代谢功能障碍至关重要.
- 在肥胖增值税中Tregs的确切特征和监管机制尚未完全理解.
研究的目的:
- 在肥胖的VAT中研究Tregs的表型和功能变化.
- 确定肥胖影响增值税Treg人口的机制.
- 探索树突细胞 (DCs) 在调节肥胖的VAT中的Treg功能中的作用.
主要方法:
- 在肥胖和瘦肉状态的内脏脂肪组织 (VAT) 中对Treg种群的比较分析.
- 在肥胖的人群中,树突细胞 (DC) 成熟标记物 (MHC-II,CD86,PD-L1) 的表征.
- 在体外共同培养实验中使用VAT DCs,巨细胞和脏DCs与Tregs.
- 评估Treg分化,扩散和关键标记物 (ST2,IL-10) 和细胞因子 (IL-33) 的表达.
主要成果:
- 肥胖导致增值税Tregs的减少,减少PD-1和ST2的扩散和改变表达.
- 肥胖的VAT表现出成熟的DCs,其中增加了MHC-II,CD86和PD-L1,与Treg数相反相关.
- 肥胖的VAT DCs与其他细胞类型不同,在体外显著抑制Treg分化和增殖.
- 由肥胖的增值税DC区分的Treg模仿了肥胖的增值税Treg的表型,显示了减少的ST2和IL-10.
- 肥胖会减少VAT DC中的IL-33产量,导致Treg差异化受损.
结论:
- 在肥胖期间,内脏脂肪组织树突细胞在调节Treg生成和表型方面发挥着关键作用.
- 肥胖的VAT DCs通过涉及减少IL-33的机制损害Treg功能,影响VAT Treg种群和可能与肥胖相关的炎症.
相关概念视频
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Cholesterol: Significance and Regulation
543
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
543
Obesity
498
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
498


