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肝细胞癌患者手术前和手术后全身治疗结果的比较:基于SEER数据库的研究
Yadi Liu1, Shuangshuang Sun2, Zhaoyin Chu1
1Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Frontiers in oncology
|April 3, 2024
概括
对于肝细胞癌 (HCC) 患者,在手术前接受全身疗法,与手术后的治疗相比,显著改善整体存活率 (OS) 和癌症特异性存活率 (CSS). 这一发现影响了治疗顺序,以获得更好的长期结果.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 临床研究 临床研究
背景情况:
- 肝细胞癌 (HCC) 系统治疗的最新进展.
- 与外科手术相比,系统治疗的最佳时间不确定性.
- 需要评估治疗顺序对HCC患者预后的影响.
研究的目的:
- 确定系统治疗和手术对肝细胞癌患者的长期结果的影响.
- 为了比较术前和术后系统治疗组之间的整体存活率 (OS) 和癌症特异性存活率 (CSS).
主要方法:
- 从SEER数据库 (2004-2015) 中对1918名HCC患者的分析.
- 术前与术后系统治疗组的比较,使用倾向性得分匹配 (PSM).
- 使用卡普兰-梅尔曲线和多变量考克斯比例危险模型进行生存分析.
主要成果:
- 术前系统治疗组 (1406名患者) 的中位数OS和CSS比术后组 (512名患者) 长.
- 在PSM和Cox回归后,术后系统治疗与全因死亡率 (HR:1.84) 和癌症特定死亡率 (HR:2.10) 的风险更高有关.
- 亚组分析证实了手术前全身治疗方法的优越性OS.
结论:
- 肝细胞癌患者的手术前系统治疗与更高的整体存活率和癌症特异性存活率有关.
- 系统治疗的时间显著影响了接受手术的HCC患者的长期预后.
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