油性鱼类摄入量对2型糖尿病的保护作用:从基因相关性和门德尔随机化研究的见解
Youqian Zhang1,2, Entong Ren2,3, Chunlong Zhang2,4
1Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Frontiers in nutrition
|April 3, 2024
概括
吃油性鱼可以帮助预防2型糖尿病 (T2DM). 这项研究发现了显著的反向关联,表明食用油性鱼类可以降低T2DM风险.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 代谢性疾病研究研究
背景情况:
- 观察性研究表明,油性鱼类消费与2型糖尿病 (T2DM) 之间存在联系.
- 油性鱼类摄入量与T2DM风险之间的因果关系尚不清楚.
研究的目的:
- 调查油性鱼和非油性鱼摄入量对T2DM风险的因果关系.
- 探索鱼类摄入量与T2DM之间的关联中的潜在调解因素.
主要方法:
- 使用与鱼类摄入量相关的遗传变异进行门德尔随机化 (MR) 分析.
- 进行了多变量MR (MVMR) 和中介MR分析.
- 对多个数据集进行了敏感性分析和元分析,以确保稳定性.
主要成果:
- 在油性鱼类摄入量和T2DM之间发现了显著的逆遗传相关性.
- 增加油性鱼的摄入量与降低T2DM风险 (OR=0.614) 有因果关系.
- 甘油三,BMI和25-氧维生素D水平被确定为潜在的调解剂.
结论:
- 油性鱼类的消费表明对2型糖尿病有保护作用.
- 这些发现支持油性鱼在T2DM预防策略中的潜在作用.
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