基于NHANES 2017-2020的不同血清叶酸与MAFLD和肝纤维化之间的关联
Jiacheng Cai1, Dahua Chen1, Wenjing Luo1
1The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang, China.
Frontiers in nutrition
|April 3, 2024
概括
较高的血清叶酸水平,包括全叶酸和5-甲基四叶酸 (5-MTHF),与代谢相关的脂肪肝疾病 (MAFLD) 和肝纤维化风险较低有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 代谢健康 代谢健康
背景情况:
- 代谢相关的脂肪肝疾病 (MAFLD) 是一个重新定义的疾病,强调代谢因素.
- MAFLD诊断的进展超出了非酒精性脂肪性肝病 (NAFLD).
研究的目的:
- 调查血清叶酸水平与MAFLD患病率之间的关联.
- 为了检查血清叶酸和肝纤维化之间的相关性.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2017-2020年).
- 采用多变量分析,包括后勤回归,控制混因素.
- 分析了与全叶酸和5-甲基四基叶酸 (5-MTHF) 的相关性.
主要成果:
- 增加的总叶酸和5-MTHF与受控衰减参数 (CAP) 有负相关性.
- 增加的5-MTHF与肝硬度测量 (LSM) 有负相关性.
- 血清叶酸度较高与MAFLD和肝纤维化的可能性降低有关.
结论:
- 血清中全叶酸和5-MTHF度的增加与MAFLD患病率的降低有关.
- 较高的叶酸水平与肝纤维化风险降低相关.
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