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相关概念视频

Rab Cascades01:25

Rab Cascades

2.6K
Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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Rab Proteins01:14

Rab Proteins

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Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
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Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

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Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
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MAPK Signaling Cascades01:07

MAPK Signaling Cascades

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.5K
Small GTPases - Ras and Rho01:24

Small GTPases - Ras and Rho

3.9K
Ras and Rho are small monomeric GTPases that act downstream of receptor tyrosine kinase (RTK) and regulate various cellular processes. These GTPases switch between active and inactive states by binding to guanine nucleotides.
Three regulatory proteins control their activity:
3.9K
The Ras Gene02:38

The Ras Gene

6.2K
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
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相关实验视频

Updated: Jun 29, 2025

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

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拉布46:在巨细胞功能的新型参与者.

Lucia Pedicini1, Jessica Smith1, Sinisa Savic2,3

  • 1Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK.

Discovery immunology
|April 3, 2024
PubMed
概括
此摘要是机器生成的。

Rab46是一种调节颗粒贩运的蛋白质,在巨细胞中高度表达. 它的遗传删除会影响巨细胞脱粒化,这表明它在过敏和炎症疾病机制中起着作用.

关键词:
这就是CRACR2A.EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4B EFCAB4拉布GTPases是一种GTPase.拉布46拉布46拉布46拉布46拉布脱粒化和脱粒化的方法基因组胺组胺的使用方法巨细胞 巨细胞走私和贩运的人口贩运

更多相关视频

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
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Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

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Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

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相关实验视频

Last Updated: Jun 29, 2025

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

13.1K
Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

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Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学

背景情况:

  • 乳腺细胞通过从颗粒中释放介质来调解过敏和炎症性疾病.
  • 乳腺细胞还起到涉及选择性介质释放的生理作用.
  • 人们对颗粒子类型及其独特的贩运途径知之甚少.

研究的目的:

  • 为了研究Rab46 GTPase在巨细胞功能中的作用.
  • 探索Rab46的参与刺激依赖性颗粒贩运在巨细胞.

主要方法:

  • 评估了人类和小鼠巨细胞中的Rab46表达.
  • 在巨细胞中利用了Rab46的遗传删除.
  • 分析了对各种刺激的反应中的瘤细胞脱粒化.

主要成果:

  • 拉布46在人类和小鼠丸细胞中都高度表达.
  • Rab46遗传删除显著影响质细胞脱粒化.
  • 删除Rab46的效果取决于特定的刺激和巨细胞亚型.

结论:

  • 拉布46在巨细胞脱粒化中起着至关重要的作用.
  • 在巨细胞中Rab46的功能是刺激和亚型依赖的.
  • 进一步对Rab46在巨细胞贩运中的研究可能会揭示巨细胞介导疾病的治疗点.