脏副甲状腺功能障碍 - - 在封装性腹膜硬化症的发展中是一个危险因素
Zia Moinuddin1,2, Kelvin Wang1,2, Catherine Fullwood3,4
1Department of Renal and Pancreas Transplantation, Manchester Royal Infirmary (National Commissioning Group (NCG) funded United Kingdom Referral Centre for EPS Surgery), Manchester, United Kingdom.
Frontiers in endocrinology
|April 3, 2024
概括
腹膜透析 (PD) 患者的高和酸盐水平是封装腹膜硬化症 (EPS) 的危险因素. 管理骨矿物代谢可能会降低患EPS的风险,EPD是一种严重的PD并发症.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 骨和矿物质的新陈代谢
- 腹腔周围透析 腹腔周围透析
背景情况:
- 封装周周硬化 (EPS) 是长期周周透析 (PD) 的罕见但严重并发症.
- 腹结石在EPS病变发生中的作用尚不清楚.
- 在PD患者中异常的骨矿物代谢可能导致腹结石化并触发EPS.
研究的目的:
- 调查骨矿物代谢标志物与PD患者中EPS的发展之间的关联.
- 为了比较EPS患者和非EPSPD对照者之间骨矿物标记的时间变化.
主要方法:
- 一项涉及46名EPS患者和46名非EPSPD对照者的比较研究.
- 在PD的持续时间内分析每四个月血清,,甲状腺激素和性酸酶 (ALP) 的水平.
- 使用线性混合模型和后勤回归的统计分析.
主要成果:
- 与对照组相比,EPS患者的平均血清 (2.51 vs. 2.41 mmol/L) 和ALP (248.00 vs. 111.13 IU/L) 水平显著高于对照组.
- 后勤回归表明,PD期间血清和酸盐水平升高,EPS的风险分别增加了4.5倍和2.9倍.
结论:
- 血清和的升高被确定为PD患者EPS发展的显著风险因素.
- 这些不平衡可能会促进腹结石和硬,可能引发EPS.
- 在PD患者中优化二次性甲状腺功能障碍症的管理可以减轻EPS风险.
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