糖尿病在聚光灯下:当前的知识和光生物调节利用的前景
Quentin Perrier1, Cécile Moro2, Sandrine Lablanche3
1Univ. Grenoble Alpes, INSERM U1055, Pharmacy Department, Grenoble Alpes University Hospital, Laboratory of Fundamental and Applied Bioenergetics, Grenoble, France.
Frontiers in endocrinology
|April 3, 2024
概括
光生物调节 (PBM) 通过改善血糖控制,有望治疗糖尿病并发症,如神经病变和伤口愈合不良. 对糖尿病视网膜病变和肌肉恢复需要进一步的研究.
科学领域:
- 生物医学工程 生物医学工程
- 内分泌学 在内分泌学.
- 再生医学是一种再生医学.
背景情况:
- 糖尿病是一种全球性健康问题,其并发症如神经病变和伤口愈合障碍等问题日益增加.
- 目前的治疗需要创新的治疗策略来管理高血糖症及其后果.
- 光生物调制 (PBM) 是一种使用低能光的非侵入性疗法,通过线粒体激活提供潜在的生物益处.
研究的目的:
- 审查关于糖尿病及其并发症的光生物调制 (PBM) 的临床前和临床证据.
- 评估在ClinicalTrials.gov注册的关于糖尿病中PBM的临床试验.
- 确定PBM在治疗糖尿病神经病变,伤口愈合,视网膜病变和血糖控制方面的有效性.
主要方法:
- 对糖尿病中PBM的临床前和临床研究进行系统审查.
- 从临床试验数据库中分析临床试验数据.
- 评估PBM对代谢参数,减轻疼痛和组织再生的影响.
主要成果:
- 87项涉及5,837名患者的临床试验研究了糖尿病的PBM.
- 在糖尿病神经病变中,PBM 显示减少疼痛并改善生活质量.
- 研究表明,PBM增强了血管生成和原密度,用于糖尿病伤口愈合.
- PBM对血糖控制产生积极影响,改善葡萄糖耐受性和胰岛素耐药性.
- 关于PBM对糖尿病视网膜病变的影响的证据仍然没有确定性.
结论:
- 光生物调制 (PBM) 是糖尿病神经病变,伤口愈合和血糖控制的有前途的辅助疗法.
- 标准化PBM参数和进一步严格的临床试验对于最佳的方案至关重要.
- 需要进一步研究PBM对糖尿病视网膜病变和肌肉恢复的影响.
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