在新斯科舍省的献血者中,SARS-CoV-2的血清流行
Sheila F O'Brien1,2, Shelley L Deeks3,4, Todd Hatchette5,6
1Epidemiology & Surveillance, Canadian Blood Services, Ottawa, Ontario, Canada.
概括
新斯科舍亚州的献血者在Omicron之前显示了较低的SARS-CoV-2感染率,到2022年8月,血清流行率上升至50.8%. 疫苗抗体在2021年达到100%,表明尽管感染激增,但免疫力普遍存在.
科学领域:
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 监测累积的SARS-CoV-2感染率至关重要,独立于测试协议.
- 这项研究检查了新斯科舍省在COVID-19大流行期间 (2020年5月至2022年8月) 献血者血清流行率.
- 该分析将血清流行与公共卫生政策和报告病例数据相关联.
研究的目的:
- 描述新斯科舍亚州献血者的SARS-CoV-2血清流行情况.
- 分析随着时间的推移感染和疫苗接种抗体的趋势.
- 确定血清阳性预测因素,并将发现与公共卫生措施相关联.
主要方法:
- 测试了24258个献血样本的抗核体 (感染) 和抗尖峰 (疫苗接种) 抗体.
- 抗体检测发生每月从2020年5月到2022年8月 (感染) 和2021年1月到2022年8月 (接种疫苗).
- 使用多变量后勤回归和分析省级NAAT阳性病例率.
主要成果:
- 反N血清流行率从3.8% (2022年1月) 增加到50.8% (2022年8月),明显超过了一般人口病例率.
- 疫苗抗体在2021年达到100%,最初在老年捐赠者中,然后在年轻人群中.
- 年轻,黑人,土著和种族化的捐赠者显示出更高的感染抗体流行率 (p < 0.01).
结论:
- 直到Omicron变种出现之前,SARS-CoV-2感染率仍然很低,导致接种疫苗的捐赠者广泛感染.
- 核酸放大测试 (NAAT) 准确地反映了病例,直到Omicron,之后血清流行率提供了更好的感染指标.
- 血清流行数据提供了对人口免疫力和感染动态的关键见解,超出了报告病例数.
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