在跨性别青少年的性别确认激素治疗期间的实验室变化
Kate Millington1,2, Janet Y Lee3,4,5, Johanna Olson-Kennedy6
1Division of Pediatric Endocrinology and Adolescent Medicine, Hasbro Children's Hospital, Providence, Rhode Island.
Pediatrics
|April 3, 2024
概括
对于接受性别肯定激素治疗 (GAHT) 的跨性别和性别多样性青少年的常规实验室监测,在前六个月内很少出现异常. 这些发现表明,目前的查指南可能会为这一群体进行调整.
科学领域:
- 内分泌学 在内分泌学.
- 青少年医学 青少年医学
- 确认性别的护理
背景情况:
- 目前对监测跨性别和性别多样性 (TGD) 青少年的性别肯定激素治疗 (GAHT) 的指导方针来自成人研究或其他条件.
- 需要了解对接受GAHT的TGD青少年的特定实验室监测要求.
研究的目的:
- 在接受GAHT的TGD青少年中调查常见的查实验室测量.
- 评估TGD年轻人中GAHT期间实验室异常的发生率和模式.
主要方法:
- 从美国四个研究地点招募了293名TGD青少年开始GAHT的队列.
- 血红蛋白,血红素,血红蛋白A1c,肝酶 (ALT,AST),益生菌和在基线和开始后的6,12和24个月被跟踪.
主要成果:
- 血红蛋白和血红素显示了GAHT可预测的变化:雌激醇下降,丸激素增加.
- 异常血红素 (>50%) 在6.5%的受试者中发生.
- 血红蛋白A1c或肝酶没有显著变化; 雌激醇的益生菌素略有增加,而高血是罕见的和短暂的与spironolactone.
结论:
- 在TGD青少年中GAHT期间的异常实验室结果是罕见的,通常在前六个月内表现出来.
- 常规的实验室查超过六个月可能不需要其他健康的TGD青少年在GAHT.
- 这些发现可以为接受激素治疗的TGD年轻人提供最新的监测指南.
相关概念视频
Signs of Puberty
337
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
337
Testosterone: Functions and Regulation
643
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
643
Hormonal Regulation of the Menstrual Cycle
354
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
354
Major Hormones and Their Functions
387
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
387
Gonadal and Placental Hormones
1.4K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.4K
Menopause
157
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
157


