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基于NHANES数据库的系统性免疫炎症指数升高对肝肥胖症的影响分析
1Department of Emergency, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai, China. XianDing8611@163.com.
European review for medical and pharmacological sciences
|April 3, 2024
概括
高系统性免疫炎症 (SII) 是肝硬化症的危险因素. 腹腔外科手术有效地降低了脂肪肝病患者的SII风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 肝硬化症是一种常见的肝脏疾病,与全身炎症有关.
- 了解系统性免疫炎症 (SII) 在肝硬化症中的作用对于有效的管理至关重要.
研究的目的:
- 为了研究高系统性免疫炎症 (SII) 和肝硬化症之间的关联.
- 评估减肥手术对肝硬化症患者SII的影响.
主要方法:
- 利用了2017-2020年国家健康和营养检查调查 (NHANES) 中5119名参与者的数据.
- 使用 (中性粒细胞数 × 血小板数) /淋巴细胞数和肝硬化指数 (HSI) 计算SII.
- 使用多变量逻辑回归和倾向得分匹配 (PSM) 进行分析.
主要成果:
- 高SII水平被确定为肝肥胖症的独立危险因素 (OR=1.33,95% CI:1.11-1.49,p<0.05).
- 在5,119名参与者中,有2,742人患有肝肥胖症.
- 腹部外科手术显示,在调整后,SII风险显著降低.
结论:
- 系统性免疫炎症 (SII) 和肝硬化之间存在显著的相关性.
- 腹腔外科手术是一种有效的干预措施,用于减少肝硬化病患者群体中的SII.
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