在患有多发性硬化症的老年人中停止治疗
1Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Current opinion in neurology
|April 3, 2024
概括
在患有多发性硬化症 (MS) 的老年人中停止疾病修饰疗法 (DMT) 显示出混合的结果. 需要更多的研究来确定停止DMT是否对这个人群安全有效.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
背景情况:
- 衰老会影响多发性硬化症 (MS) 的进展和治疗的有效性.
- 疾病修饰疗法 (DMT) 是MS管理的标准.
- 在患有多发性硬化症的老年人中停止使用DMT需要仔细考虑.
研究的目的:
- 审查有关在患有MS的老年人中停止使用DMT的证据.
- 分析老化如何影响MS和DMT的疗效.
- 在这个人口群体中停止DMT后评估临床结果.
主要方法:
- 关于与衰老相关的生物变化的文献综述.
- 综合最近关于DMT停药结果的证据.
- 追溯观察性研究和临床试验的分析.
主要成果:
- 回顾性研究表明,在停药前使用DMT的年龄较大和时间较长与复发风险较低相关.
- 一个随机临床试验没有证实DMT停药的非劣势性.
- 目前,关于老年多发性硬化症患者中DMT戒断结果的证据是混合的.
结论:
- 关于在患有多发性硬化症的老年人中停止使用DMT的临床证据是不确定的.
- 进一步强大的临床试验和真实世界的数据是必不可少的.
- 在这个人群中停止使用DMT的临床决策的指导需要更多的支持.
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