相关实验视频

Updated: Jun 29, 2025

Tissue Collection of Bats for -Omics Analyses and Primary Cell Culture

Tissue Collection of Bats for -Omics Analyses and Primary Cell Culture

Published on: October 23, 2019

基于高吞吐量分子建模的蝙蝠嗅觉受体超级家族的进化

Tianmin Zhang^1,2, Haohao Jing¹, Jinhong Wang¹

¹College of Life Sciences, Shaanxi Normal University, Xi'an, China.

Molecular ecology resources

|April 3, 2024

概括

蝙蝠的嗅觉受体 (ORs) 在它们的进化过程中经历了显著的收缩,这表明它们对气味的依赖减少了. 这种嗅觉进化与蝙蝠的饮食适应有关.

科学领域:

进化生物学是进化的生物学.
感官生物学感官生物学
基因组学就是基因组学.

背景情况:

通过嗅觉受体 (ORs) 介导的嗅觉对于蝙蝠在食物评估和社会互动中至关重要.
蝙蝠飞行和回声定位的演变可能影响了其他感官系统,包括嗅觉,这仍然不太了解.
了解OR曲目演变提供了对蝙蝠感官适应的见解.

研究的目的:

研究蝙蝠嗅觉受体 (OR) 谱系大小和功能的进化变化.
分析与蝙蝠飞行,回声定位和饮食适应有关的OR曲目演变.
通过分子建模和对接,探索OR曲目多样性的功能影响.

主要方法:

在蝙蝠种群中对OR谱的比较基因组分析.
对ORs的蛋白质结构建模.
分子对接技术来评估OR-气味剂的结合能.
将比较基因组学与计算建模的整合.

主要成果:

在蝙蝠的进化起源期间观察到功能性OR谱的显著收缩,表明嗅觉依赖性减少.
在具有独特生态特征的蝙蝠血统中发现了OR基因扩张,收缩和调宽度的差异.
非回声定位的,吃水果的蝙蝠表现出强烈的结合亲和力以的气味剂,但没有定量 OR 剧目优势超过食虫物种.

结论:

蝙蝠的嗅觉进化与饮食适应密切相关,这是OR剧目和功能的变化证明的.
分子建模和计算对接为蝙蝠嗅觉的功能演变提供了宝贵的见解.
这些发现为未来对蝙蝠嗅觉受体功能的实验验证奠定了基础.

关键词:

蝙蝠蝙蝠蝙蝠蝙蝠是一个分子对接的分子对接.嗅觉受体是一种嗅觉受体.蛋白质建模的模型

更多相关视频

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase

Published on: April 23, 2019

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

High-throughput Analysis of Mammalian Olfactory Receptors: Measurement of Receptor Activation via Luciferase Activity

Published on: June 2, 2014

相关概念视频

Convergent Evolution

Convergent Evolution

Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Gene Families

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...

Pollination and Flower Structure

Pollination and Flower Structure

Flowers are the reproductive, seed-producing structures of angiosperms. Typically, flowers consist of sepals, petals, stamens, and carpels. Sepals and petals are the vegetative flower organs. Stamens and carpels are the reproductive organs.