源调节区域差异异异的不对称基化2-替代的1,3-二烯与化物通过催化
Xian-Wang Zeng1, Jia-Ni Lin1, Wei Shu1
1Department of Chemistry, Guangming Advanced Research Institute and Shenzhen Grubbs Institute, Southern University of Science and Technology, Shenzhen, 518055, Guangdong, P. R. China.
这项研究引入了一种催化反应,用于从简单的起始材料中合成性同质醇. 反应的区域选择性可以通过简单地改变质子源来控制,提供了一种多功能合成路线.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 不对称的合成方法
背景情况:
- 在有机合成中,开发用于控制区域选择性和酶选择性的催化方法至关重要.
- 从相同的原料中获取多种不同的丰富分子架构仍然是一个重大挑战.
- 区域分离和反选择性反应为复杂分子提供了高效的途径.
研究的目的:
- 开发一种催化方法,用于1,3-dienes与化物进行区域分离和选择性还原性基化.
- 通过改变反应参数来证明切换区域选择性的能力.
- 为了提供对增添的同质醇酒精架构的访问.
主要方法:
- 1,3-二烯和甲基的催化还原基化.
- 利用不同的质子源 (酸与) 来控制区域选择性.
- 使用不对称的催化剂来实现高的enantioselectivity.
主要成果:
- 取得了成功的同催化区域分离和反选择性还原基化.
- 使用酸作为质子源,获得了不对称的1,2-基化产物.
- 使用西兰作为化物来源,获得了不对称的4,3-基化产物.
- 该协议产生了具有两个连续和碳中心的同质醇,具有高的区域性,二性和性选择性.
结论:
- 一个新的协同催化协议使可切换的区域选择性和高反选择性在还原性基化中成为可能.
- 质子源的选择是控制反应的区域化学结果的关键因素.
- 这种方法提供了一种多功能方法,用于合成多种丰富的同质醇.
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